SUN-035 CROSS ORGANELLE STRESS RESPONSE DISRUPTION PROMOTES GENTAMICIN-INDUCED PROTEOTOXICITY AND ACUTE KIDNEY INJURY
نویسندگان
چکیده
منابع مشابه
Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury
Contrast-induced acute kidney injury (CIAKI) is a leading cause of acute kidney injury following radiographic procedures. Intrarenal oxidative stress plays a critical role in CIAKI. Nicotinamide adenine dinucleotide 3-phosphate (NADPH) oxidases (Noxs) are important sources of reactive oxygen species (ROS). Among the various types of Noxs, Nox4 is expressed predominantly in the kidney in rodents...
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Case Presentation: A 63-year-old man with prior mitral valve repair, hyperlipidemia, hypertension, and mild chronic renal insufficiency (creatinine 1 year earlier, 1.2 mg/dL) presents to the emergency department with progressive dyspnea on exertion and new anterior T-wave inversions. Subsequent laboratory testing confirms a myocardial infarction (troponin I, 11.0 ng/mL) and worsening renal insu...
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a Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, USA b Critical Care, Robert Wood Johnson University Hospital, New Brunswick, NJ USA c Robert Wood Johnson University Hospital, New Brunswick NJ, USA d Internal Medicine, Robert Wood Johnson University Hospital, New Brunswick, NJ, USA e Division of Pulmonary and Critical Care Medicine, Department of M...
متن کاملContrast-induced Acute Kidney Injury
• Objective: To review the risk factors, definition, pathophysiology, prevention, and adverse outcomes associated with the development of acute kidney injury resulting from iodinated contrast. • Methods: Case presentation and evaluation of the
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2020
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2020.02.558